Repurposed asthma drug shows blood sugar improvement among some diabetics

Repurposed asthma drug shows blood sugar improvement among some diabetics
Researchers at the University of San Diego School of Medicine have completed a study that shows that an anti-asthma drug may have a positive benefit on blood sugar levels in patients with diabetes.

After 12 weeks of taking an anti-asthma drug, a subset of patients with type 2 diabetes showed a clinically significant reduction in blood glucose during the randomized, double blind, placebo controlled clinical trial.

The results of the trial were published in Cell Metabolism.
“When we looked at the drug-treated group we saw a bimodal distribution, that is, there were some responders and some non-responders. We didn’t understand why, so we did a molecular analysis from biopsies of fat cells we took from patients at the beginning and end of the study,” said Alan Saltiel, PhD, director of the UC San Diego Institute for Diabetes and Metabolic Health.

“In the responder group, the level of inflammation in fat was higher than in the non-responder group at the beginning of the study, indicating that there is something about inflammation that predisposes a person to respond. And, what was really amazing was that there were more than 1,000 gene changes that occurred exclusively in the respinders”.

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