Tag: medicine

Repurposed asthma drug shows blood sugar improvement among some diabetics

Repurposed asthma drug shows blood sugar improvement among some diabetics
Researchers at the University of San Diego School of Medicine have completed a study that shows that an anti-asthma drug may have a positive benefit on blood sugar levels in patients with diabetes.

After 12 weeks of taking an anti-asthma drug, a subset of patients with type 2 diabetes showed a clinically significant reduction in blood glucose during the randomized, double blind, placebo controlled clinical trial.

The results of the trial were published in Cell Metabolism.
“When we looked at the drug-treated group we saw a bimodal distribution, that is, there were some responders and some non-responders. We didn’t understand why, so we did a molecular analysis from biopsies of fat cells we took from patients at the beginning and end of the study,” said Alan Saltiel, PhD, director of the UC San Diego Institute for Diabetes and Metabolic Health.

“In the responder group, the level of inflammation in fat was higher than in the non-responder group at the beginning of the study, indicating that there is something about inflammation that predisposes a person to respond. And, what was really amazing was that there were more than 1,000 gene changes that occurred exclusively in the respinders”.

Source and further reading:
https://health.ucsd.edu/news/releases/Pages/2017-07-05-repurposed-asthma-drug-shows-blood-sugar-improvement-among-some-diabetics.aspx

Journal article:
http://www.cell.com/cell-metabolism/fulltext/S1550-4131%2817%2930348-0

#research

A New Drug May Be Able to Completely Reverse Diabetes

A New Drug May Be Able to Completely Reverse Diabetes

“In the global community, the number of people with diabetes has been on the rise since 1980,with 422 million people diagnosed by 2014. The U.S. alone has experienced a substantial rise in the incidence of diabetes, with the number of Americans diagnosed increasing from 5.5 million in 1980, to 22 million in 2014—a more than 300 percent increase in less than 40 years.

A team of researchers, led by Stephanie Stanford at the University of California, San Diego, is proposing a solution in the form of a single pill that aims to restore insulin sensitivity in diabetic patients. Type 2 diabetes develops when the body’s response to insulin, the hormone responsible for regulating sugar in our blood, weakens. A number of genetic and lifestyle factors will influence whether or not someone develops this type of diabetes in their lifetime…”

#future =

https://futurism.com/a-new-drug-may-be-able-to-completely-reverse-diabetes/